Heart disease and How Can Curcumin Help

How Can Curcumin Help Heart Disease

14 Research Backed Benefits of Curcumin for Heart Health

Over 200 research studies have investigated the therapeutic efficacy of turmeric and curcumin in various heart conditions. Not only does turmeric protect the heart but it also combats various metabolic conditions that could serve as a risk factor to the development of heart diseases.

Heart disease contributes significantly to the mortality rate across the world today. In fact, heart disease is the leading cause of death globally.What’s more concerning is that it is not an ‘old age’ disease anymore. The more young and middle-aged population is suffering from heart disease today than ever before in history. Heart disease or cardiovascular diseases are a very broad term for a number of conditions that directly or indirectly affect heart health.

  • Coronary heart disease is the most common condition where the blood vessels connected with the heart are damaged.
  • Atherosclerosis is the build of plaque in blood vessels that obstructs blood flow.
  • Coronary heart disease is the most common condition where the blood vessels connected with the heart are damaged.
  • Heart attack or myocardial infarction is when blood flow to the heart is blocked by clots.
  • Strokes are conditions when blood vessels providing blood to the brain are blocked.
  • Arrhythmia is a condition where the rhythm of the heart is abnormal.

Risk factors that lead to heart diseases involve obesity, lack of exercise, unhealthy diet, use of tobacco, alcohol as well as stress-related factors.

Preventing cardiovascular diseases is the first line of defence which would translate as a change in diet as well as lifestyle. In those suffering from heart conditions medications are provided to treat cholesterol, lower blood pressure, prevent clot formation. In certain conditions, surgical procedures may be required. These procedures not only involve risks but also lead to a heavy burden of costs in healthcare.

Wouldn’t it be nice if there is just only one compound that does all these things: lowers cholesterol, reduces blood pressure, protects heart and blood vessels, helps in weight loss, prevent clot formation, etc. There is one such compound and its name is curcumin.

1. It has a cardioprotective effect

Curcumin has a cardioprotective action- its pharmacological properties help in protecting the heart and also benefits individuals with various heart conditions. These pharmacological properties involve antioxidant action, anti-inflammatory action, antiplatelet activity, etc.

Cardiac hypertrophy is a condition in which the heart muscle thickens and reduces the size of heart chambers. Animal studies show that curcumin can benefit individuals who suffer from cardiac hypertrophy by affecting genetic expressions.

Cardiac arrhythmia is an abnormal rhythm of the heart. A study published in the International Journal of Cardiology, 2009 suggests that curcumin’s anti-inflammatory action and ability to affect calcium homeostasis can benefit people who suffer from arrhythmia and also prevent arrhythmia.

What does this mean?
Curcumin found in turmeric protects heart. Research confirms its role in various heart conditions like congenital heart disease, cardiac arrhythmia, cardiac hypertrophy, ischemia-reperfusion injury, chemotherapy induced cardiotoxicity etc.

2. It has an anti-inflammatory effect

Turmeric and curcumin have natural anti-inflammatory property. In inflammatory conditions like arthritis, curcumin is found to counteract inflammation as effectively as non-steroidal anti-inflammatory drugs.

Curcumin acts on major proteins that regulate the inflammatory process like Nuclear factor kappa B. It reduces the production of inflammatory cytokines and also inhibits their action. It prevents the migration of immune cells to the site of inflammation. This anti-inflammatory effect of curcumin and turmeric is beneficial in various heart conditions like myocarditis, cardiac fibrosis, cardiotoxicity, etc.

What does this mean?
Turmeric’s anti-inflammatory action benefits in heart health and prevention of various heart diseases such as myocarditis, cardiac fibrosis, atherosclerosis etc.

3. It is an antioxidant

One of the prime reasons why antioxidants are touted to be beneficial for health is because they are heart friendly agents.

Apart from improving the body’s antioxidant defense, dietary antioxidants can help in reducing inflammation and lowering cholesterol which, in turn, benefit heart health and can reduce the risk of heart diseases.

Curcumin and curcuminoids are strong antioxidants and their antioxidant activity is comparable to that of vitamin C and E.

Research shows that curcumin’s antioxidant action can protect from obesity-induced cardiac surgery, cardiotoxicity, atherosclerosis, diabetes-related heart conditions, and various other heart conditions.

4. It protects from heart attacks

Curcumin is cardioprotective in nature. Curcumin is found to act on the genes that affect the cardiac repair and cardiac function after a heart attack. Curcumin is found to improve the antioxidant profile, reduce inflammation and also regulates the repair of cells found in heart muscles after a heart attack.

Researchers suggest that dietary curcumin is beneficial for those recovering from a heart attack as it facilitates proper cardiac repair. A study published in the American Journal of Cardiology, 2012 examined the effect of curcuminoid therapy in those undergoing specific heart surgery. The idea was to see whether curcumin provides sufficient cardioprotection after the surgery as this surgery is associated with poor outcomes and the current treatment options to protect the heart are limited. The 121 patients enrolled in the study received 4g of curcuminoids or a placebo per day for 3 days prior to surgery and continued till 5 days after the surgery.

It was found that the incidence of heart attack was 30% in the placebo group while it was only 13.1% in curcuminoids group. Improvement in antioxidant and inflammatory status was also observed. (Important note from Oshun Health: Curcumin is a blood thinner and should never be taken before surgery unless under doctor’s supervision.)

What does this mean?
Curcumin offers cardioprotection that can help prevent heart attack. Dietary curcumin is found to be beneficial in promoting heart repair in those who have suffered from heart attack.

5. It reduces the risk of atherosclerosis

Atherosclerosis is characterized by a build-up of plaque in blood vessels due to elevated levels of cholesterol and fats. This constricts blood vessel thereby affecting blood flow and blood pressure. A study published in Atherosclerosis, 2014 demonstrates that curcumin can attenuate diet-induced atherosclerosis. It ameliorates dyslipidemia (abnormal lipid/fat levels in the blood), reduces expression of inflammatory enzymes, prevents the formation of fatty streaks (precursors to plaque build up in blood vessels) and also protects liver function. However these effects are found to be dose dependent, researchers suggest that a medium dose of curcumin in the diet is more effective than high dose curcumin in atherosclerosis.

Curcumin acts on various genetic expression, liver function as well as raises antioxidant defenses in order to prevent atherosclerosis. A study published in The Journal of Nutritional Biochemistry,2014 investigated the effect of curcumin in type 2 diabetes patient who was at high risk of developing atherosclerosis. Curcumin was found to regulate hormones linked with fat metabolism and also to reduced pulse wave velocity (a parameter that indicates the stiffness of arteries or how blocked they are in terms of obstructed blood flow).

Other changes observed were the reduction in body fat, improvement in insulin activity, reduced blood lipid levels etc. Curcumin therapy successfully improved metabolic health thereby preventing atherosclerosis in type 2 diabetes.

What does this mean?
Turmeric contains curcumin which can help prevent atherosclerosis as an antioxidant and by regulating cholesterol levels and liver function. It helps improve overall metabolic health in order to prevent atherosclerosis.

6. It benefits in myocarditis

Myocarditis is inflammation of the heart muscle. Turmeric’s anti-inflammatory properties can support individuals with myocarditis. A study published in the Journal of Cardiovascular Pharmacology and Therapeutics, 2013 demonstrated curcumin’s therapeutic efficacy in viral myocarditis. It was found that curcumin brought down levels of inflammatory enzymes by acting on key proteins involved in inflammation.

Mito et.al have proven via an animal study that curcumin counteracts inflammation in autoimmune myocarditis.

Other studies point out that curcumin’s immunomodulatory (ability to regulate immune function) and antioxidant action protect heart function in autoimmune myocarditis. These properties can help in protecting heart function and preventing the progress of myocarditis, thus making curcumin a novel therapy in myocarditis.

What does this mean?
Various pharmacological properties of turmeric and curcumin such as anti-inflammatory, antioxidant and anti-microbial action benefit in treatment of myocarditis. Curcumin’s immunomodulatory action can help control inflammation in autoimmune myocarditis.

7. It improves vascular function

Vascular function or endothelial function refers to the health of blood vessels. This parameter indicates the balance between constriction and relaxation of blood vessels thereby affecting blood flow and blood pressure. Endothelial dysfunction is when this state is imbalanced. Curcumin is found to protect from endothelial dysfunction caused by drug induced toxicity.

A recent study published in the Journal of Nutrition and Metabolism, 2016 demonstrated that supplementation of 200mg curcumin every day for 8 weeks brings about a significant increase in flow-mediated dilation (FMD) – an indicator of improved blood flow and better endothelial function.FMD.

Based on the results of this clinical trial researchers suggested that simple oral supplementation of curcumin can improve cardiovascular health. A really interesting study published in Nutrition Research, 2012 demonstrated that oral curcumin intake is as efficacious as moderate aerobic exercise in improving endothelial function in postmenopausal women.

What does this mean?
Endothelial dysfunction indicates impaired health of blood vessels. Simple curcumin supplementation or dietary turmeric is found to improve vascular function in as little as single consumption as well as over a period of 2-3 months.

8. It may help to counteract thrombosis

Thrombosis or clot formation can present serious health complications. This is where curcumin’s anti-platelet property can help. A study published in Thrombosis Research, 1995 reveals that curcumin has an anti-thrombotic action. Further research reveals that curcumin is as effective as aspirin (an anticoagulant or blood thinner) in treating thrombosis. However, these findings need to be confirmed via human studies.

What does this mean?
Curcumin and turmeric’s anti-platelet action may help maintain anti-coagulant status and benefit in thrombosis.

9. It benefits individuals with cardiac fibrosis

Many heart diseases are associated with fibrosis. Cardiac fibrosis is scarring of the cardiac tissue which leads to the thickening of the tissue. Thickening leads to the reduction of heart chambers thus causing arrhythmia.

A recent study published in Drug Design, Developmental and Therapy, 2016 shows that curcumin has an anti-fibrotic action. It acts via the SIRT1 gene which is famous for its anti-aging action but also plays a significant role in fibrosis.

Curcumin may also benefit individuals with cardiac fibrosis by reducing collagen synthesis and facilitating collagen breakdown. It also inhibits the activity of enzymes that initiate scarring of the cardiac tissue.

In their animal study, Meng et.al proved that curcumin attenuates cardiac fibrosis occurring as a result of hypertension or high blood pressure.

What does this mean?
Curcumin is natural anti-fibrotic agent. Research proves that curcumin can be a novel therapeutic agent in cardiac fibrosis.

10. It can have a therapeutic effect on coronary artery disease

Coronary arteries are those that are directly linked to the heart via the aorta. Coronary artery disease is when plaque builds up in these arteries. This is one of the most common heart diseases.

As mentioned previously, curcumin has an  anti-atherosclerotic effect – it prevents the buildup of plaque.

In a study, patients with coronary artery disease were treated with 500mg curcumin 4 times a day for 2 months. Curcumin treatment brought about a decrease in blood sugar levels, cholesterol levels, as well as triglyceride levels. However, no significant change in inflammatory parameters was observed.

What does this mean?
Curcumin’s anti-atherosclerotic activity and anti-platelet property benefits individuals with  coronary artery disease.

11. It may lower blood pressure

Curcumin may lower blood pressure by acting on angiotensin receptors; angiotensin being one of the hormones that regulate blood pressure and kidney function.

Curcumin derivatives have been identified to have vasorelaxant properties – they help blood vessels relax for better blood flow and reduced blood pressure. Nanocurcumin has proven anti-hypertensive property and this activity is comparable to catopril, a prescription drug used to treat blood pressure.

What does this mean?
Turmeric helps to lower blood pressure by acting on various enzymes that regulate and control blood pressure levels. It also helps alleviate hypertension by acting on other aspects of metabolic health that could serve as a risk factor for developing high blood pressure.

12. It lowers cholesterol

Curcumin has an hypocholesterolemic effect in other words it lowers cholesterol levels. There are many mechanisms involved in this activity, for example, curcumin acts on the genes involved in fat metabolism in order to lower cholesterol levels.

A study was conducted to assess the effect of curcumin on lipid levels in patients suffering from acute coronary syndrome. 75 patients participated in this study.

Curcumin was given in the following doses:

  • Low dose: 3 times 15mg/day
  • Moderate dose: 3 times 30mg/day
  • High dose: 3 times 60mg/day

A dose dependent change in lipid and cholesterol level was observed with curcumin therapy. Low dose curcumin brought about a better reduction as well as an increase in HDL cholesterol.

Researchers concluded that low dose curcumin is efficacious in reducing cholesterol- and LDL levels.

What does this mean?
Curcumin helps lower cholesterol levels and this protects heart and vascular health by preventing atherosclerosis, hyperlipidemia etc.

13. It benefits in metabolic health

Metabolic health is very intricately linked with heart health. Metabolic syndrome is a broad term for a number of health conditions like high cholesterol levels, high blood pressure, obesity, etc.

Turmeric and Nigella sativa seed supplementation for 4 weeks is found to improve all parameters associated with metabolic syndrome.

Results of a clinical trial published in Phytotherapy Research, 2016 demonstrated that curcumin supplementation brought a significant reduction in liver fat and brought about a 78.9% improvement in the disease.

Turmeric and curcumin’s multiple benefits and ability to lower blood sugar levels is found to benefit in diabetes and protect against diabetes-induced cardiac risk.

What does this mean?
Curcumin treats various aspects of metabolic health and helps ameliorate various conditions like metabolic syndrome, diabetes and fatty liver disease which otherwise would pose a risk for heart diseases.

14. It protects the heart against aging

Turmeric and curcumin are excellent natural agents for the prevention of age-related health deficits. (Read Turmeric for Aging)

Khurana et.al have identified curcumin as one of the plant polyphenols that can help protect the aging heart. Santos-Parker et.al demonstrated that high dose curcumin supplementation for 12 weeks improved endothelial function in elderly and middle-aged individuals. Curcumin’s antioxidant activity was responsible for this action.

The combination of endurance exercise and curcumin intake is found to benefit and improve vascular function in postmenopausal women.

What does this mean?
Curcumin’s antioxidant and cardioprotective property benefits and supports heart health in aging.

Precautions

Turmeric in the diet is safe, but large amounts may cause gastric upset. Therefore it’s best to start with small doses and increase gradually. (Read Side effects of Turmeric)

One of the important precautions in relation to cardiovascular diseases is that turmeric has anti-platelet properties proven by animal studies. Though minimal amounts of dietary turmeric should not pose any problem, it is advisable to consult a health practitioner with regards to this, especially when you are already taking blood thinners.

Also, due to the anti-platelet properties of turmeric, it is advised to discontinue turmeric two weeks prior to surgery in order to avoid bleeding risks.

Turmeric supplements should be avoided during pregnancy and lactation.

Curcumin at low doses can cause gall bladder contractions, so if suffering from gallstones or gallbladder obstruction, avoid curcumin supplements. (Read Should you take turmeric if you have gallstones)

Turmeric as a spice is high in oxalates hence it is advisable to limit intake of turmeric as a spice in case of gout or kidney stones. (Read Is Turmeric safe in gout? Does Turmeric cause kidney stone?)

Curcumin in turmeric does interfere in drug metabolism. Therefore it is advised to avoid taking curcumin supplements concomitantly with other medications.

Consult a health practitioner prior to taking turmeric supplements.

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Fulvic Acid as a Potent Antiviral

Reading time: 10 minutes

Research shows that humic acid, of which fulvic acid forms part, binds so strongly to viruses that it can actually displace them from a cell surface. In vitro studies have shown, for example, that if you allow herpes simplex viruses to attach to host cells and then add humic acid to the solution, it will displace viruses from infected cell surfaces. That is, humic acid has a greater affinity for the virus than the virus does for the host cell. Thus, humic acid can actually displace a virus even after it has attached itself to the surface of a cell.[6]

The following article was originally posted by Michael Ash for the website of Clinical Education, a ‘Not for Profit’ organisation that brings a range of educational experiences to healthcare professionals. Follow Clinical Education by clicking on the following link: https://www.clinicaleducation.org/

The interview with Richard J Laub, MS, PhD, CChem, FRSC, was conducted by Focus Allergy Research Group.

*Note by Oshun Health: Humic Acids referred to in this article is the collective name for both humic acid and fulvic acid. In order to utilise humic acid, it is broken down to fulvic acid in the human gut. This is because humic acid is not soluble at the low pH (acidic) level of the stomach whereas fulvic acid is soluble at any pH level. The antiviral properties referred to in the article, therefore, applies to fulvic acid as well as humic acid.

An Interview with: Richard J Laub, MS, PhD, CChem, FRSC, is a chemist with nearly 150 peer-reviewed published research papers, sixteen patents, and numerous invited reviews and symposium presentations. He was formerly a professor of chemistry at The Ohio State University and San Diego State University, was a fellow of the Royal Society of Chemistry in London, England, was an Alcoa fellow in San Diego, and a Science Research Council fellow in Swansea, Wales. For the last 17 years, Dr. Laub has focused exclusively on sourcing, analysing, studying, extracting and purifying humic acid, a remarkable high-mineral, healing substance with potent antiviral properties, found in ancient soil deposits.

Focus: You have devoted the last 17 years of your life to researching humic acid, an extract of ancient organic soil deposits. These ancient soil deposits—named humus, or humin, from the Greek word for soil—can be found all over the world and contain highly-concentrated minerals and healing substances. It’s interesting that in essence, the soil that nourishes plant life–and later the plant that dies and becomes part of the soil–contains such potent healing substances. Can you give us some basic facts about humic and fulvic acids before we discuss the health benefits?

RJL: Both humic and fulvic acids are extracts from composted organic matter and prove to be excellent mineral supplements. They excel at providing all the trace minerals we need. Fulvic acid is a small and somewhat rigid molecule, with a molecular weight of about 1,500 daltons (a dalton is a unit of mass commonly used in chemistry). Humic acid is equally potent as a mineral supplement, but is a much heavier, bigger molecule. It weighs about 50,000 daltons. Humic acid is flexible, because it is made up of many chains of molecules. It looks a bit like a series of wagon wheels, one inside the other, with spokes going from one wheel to the next. This flexibility is a very important contributor to its antiviral properties.

Focus: What do these very different shapes—small and rigid, or large and flexible—mean in terms of human health?

RJL: Because of its size and flexibility, certain humic acids from particular soil deposits turn out to be potent, broad-spectrum antivirals. That is because humic acid contains many kinds of “functional groups” (specific groups of atoms) that can bind to a multitude of viruses. Research has shown certain humic acids to be effective in vitro against a wide range of viruses, including influenza, HSV, HIV, and others.[1],[2],[3],[4],[5]

Focus: How exactly does humic acid bind to a virus?

RJL: Binding occurs through hydrogen bonding. Electropositive atoms attract electronegative atoms. These are the same forces that hold DNA together. What is remarkable is that humic acid, with its many kinds of functional groups, binds more strongly to viruses than do our own cells. Certain humic acids from certain soil deposits are essentially like a really, really sticky piece of Velcro. Viruses also have really sticky sites—that’s how they manage to bind to a host cell. When these two very sticky pieces of Velcro come together they bind together very strongly.

Focus: Can you explain what a virus does once it attaches to a cell receptor?

RJL: It essentially pokes a hole in the cell, and injects either its RNA or DNA–its genomic material–into the cell. At that point the virus has essentially spent itself, but the viral material inside the cell uses the cell’s machinery to create more viruses, which then leave the cell and go on to bind to and infect other cells.

Focus: What happens to a virus when it binds to humic acid instead of a cell surface?

RJL: Humic acid essentially neutralises a virus’s chemical “stickiness”. Doing so in turn prevents the virus from reproducing since it can no longer attach (“fuse”) to the surface of a host cell. The immune system can then begin to eliminate the virus (largely through the action of macrophages). Also, viruses don’t live forever: if not allowed to reproduce, influenza viruses, for example, die out in 36-48 hours.

Focus: What happens if viruses have already attached to your cells? Can humic acid help?

RJL: Humic acid binds so strongly to viruses that it can actually displace them from a cell surface. In vitro studies have shown, for example, that if you allow herpes simplex viruses to attach to host cells and then add humic acid to the solution, it will displace viruses from infected cell surfaces. That is, humic acid has a greater affinity for the virus than the virus does for the host cell. Thus, humic acid can actually displace a virus even after it has attached itself to the surface of a cell.[6]

Focus: That’s quite amazing—that this natural substance can displace viruses that have already locked onto cells. Is this true of any humic acid from around the world?

RJL: No. Humic acid varies dramatically from site to site. Humic acids from different deposits have very different physicochemical properties. Just like coal—the coal from South Africa is very different in makeup than the coal from Birmingham in Britain. For instance, one of the better-known humic acid deposits in the United States occurs in the state of New Mexico, where humic acid is mined for agriculture–as a fertiliser–and also for the petroleum industry as a drilling mud additive. From an agricultural standpoint New Mexico humic acid is great, but it is not very effective at combating human viruses. A lot of the research I carried out in the early days was simply obtaining samples of humic acid from around the world and testing them to see which ones were efficacious against human viral disease. Remember, humic acid is the result of composted organic matter that is 50-100,000 years old, and that can be found almost anywhere—places where there are freshwater deposits and vegetation living around freshwater lakes, other places where there are saltwater deposits and decomposed organic matter at the edge of marine environments. Some humic acids come from decomposed forests, others from marshes, peat bogs, or scrub-brush. Any plant can be composted into humic acid, but the enormous variety of plant life means that each source of humic acid is unique.

Focus: Once you found the ideal antiviral humic acid, what did you do?

RJL: The next challenge was to purify and sterilise it without degrading it. When you first dig humic acid out of the ground it is dark-brown or even black. Shilajit is a very crude form of humic acid that has been used around the world for hundreds (if not thousands) of years. The most familiar form of humic acid looks like coal, and is sometimes called leonardite or brown coal—though it isn’t actually coal. So, the challenge was to extract the humic acid without damaging it. Methodologies suitable for sterilisation of the final processed product also took very considerable research and development. (The original microbes that created the humus are of course long since dead, but other bacteria and moulds flourish in such soil deposits.) Overall, ten solid years of research and development were required to identify a quality source of humic acid that could also be purified and sterilised without diminishing its effectiveness as a human antiviral agent.

Focus: If one takes humic acid orally, when do peak blood levels occur?

RJL: Peak levels occur at about four hours. By eight to twelve hours the substance is pretty much cleared out of the bloodstream.

Focus: Do you think it has any other special properties beyond being a great mineral source and a potent antiviral?

RJL: Some researchers claim it boosts the immune system, but I’m not convinced it does so directly.[7] I think that humic acid’s wide spectrum of important trace minerals, coupled with its antiviral properties, result in a stronger immune system indirectly. Some of the trace minerals are present in very, very tiny amounts—just a few parts per million—but that’s exactly what we need to support enzyme functions among other things. I also think there are a lot of viruses we are all carrying that haven’t yet been identified (“stealth” viruses). But humic acid will bind to them, regardless.

Focus: That just shows you the broad-spectrum action of humic acid, so that it’s likely to work on many viruses we carry that have not yet been identified. I assume you take it yourself?

RJL: Of course. And I haven’t had a cold or the flu since 2004. Not one.


References

[1] F. J. Lu, S. N. Tseng, et al. In Vitro Anti-Influenza Virus Activity of Synthetic Humate Analogues Derived from Protocatechuic Acid. Arch. Virol. 2002, 147(2), 273-284 View Abstract

[2] C. E. J. van Rensburg, J. Dekker, et al. Investigations of the Anti- HIV Properties of Oxihumate. Chemotherapy 2002, 48(3), 138-143. View Abstract

[3] G. Kornilaeva, A. Becovich, et al. New Humic Acid Derivative as Potent Inhibitor of HIV-1 Replication. Med. Gen. Med. 2004, 6(3), A10360 View Summary PDF

[4] R. Kloecking, B. Helbig, G. Schotz, et al. Anti-HSV-1 Activity of Synthetic Humic Acid-Like Polymers Derived from p-Diphenolic Starting Compounds. Arch. Chem. Chemother. 2002, 13(4), 241-249

[5] Laub Biochem Specialty Labsl, 2001-2002, research conducted by contract for Virology Branch of the Antiviral Research and Antimicrobial Chemistry Program (Dr. Christopher Tseng, Program Officer), Division of Microbiology and Infectious Diseases (DMID) Screening and Testing Program for Antiviral, Immunomodulatory, Antitumor and/or Drug Delivery Activities, National Institutes of Allergy and Infectious Diseases (NIAID), under the auspices of the National Institutes of Health (NIH, Bethesda, Maryland)

[6] Laub Biochem Specialty Labs, Humic Acid Inhibition of HSV Infection. 1998

[7] G. K. Joone, J. Dekker, et al. Investigation of the Immunostimulatory Properties of Oxihumates. Z. Naturforsch. C: J. Biosci. 2003, 58(3/4) 263-267. PMID: 12710739 View AbstractLinkedInFacebookTwitterEmailPrintMor

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Fulvic Acid as a Potent Antiviral

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